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Synthesis and base pairing properties of 9-deazapurine N7-nucleosides in oligonucleotide duplexes and triplexes
P Leonard1, T Wiglenda, F Seela
1Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
The 9-deazaguanine N7-2'-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonucleotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N7-2'-deoxyribofuanosides.