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Dealkylation of phosphonate esters with chlorotrimethylsilane
A J Gutierrez1, E J Prisbe, J C Rohloff
1Department of Chemical Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, USA.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.