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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Published on: May 15, 2012

A novel approach for the solid phase synthesis of DNA-peptide conjugates

T Kubo1, K Dubey, M Fujii

  • 1Department of Chemistry, Kyushu School of Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.

Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
PubMed

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Peptide Bonds02:35

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...