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Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA
A G Pokrovsky1, T R Pronayeva, N V Fedyuk
1SRC Virology and Biotechnology Vector, Koltsovo, Russia, 630059.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3'-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.