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Synthesis and evaluation of alpha-LNA
N K Christensen1, J K Dalskov, P Nielsen
1Department of Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Three different synthetic routes to the alpha-configured LNA thymine monomer starting from D-allose or D-arabinose were investigated. The introduction of one or four alpha-LNA monomers into alpha-DNA had a destabilizing effect on the duplexes. However, a fully modified alpha-LNA sequence displayed strong recognition of complementary RNA, but no transition with DNA.