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Antisense properties of 2'-O-dimethylaminooxyethyl (2'-O-DMAOE) oligonucleotides
T P Prakash1, A M Kawasaki, J F Johnston
1Isis Pharmaceuticals, 2292 Faraday Ave., Carlsbad, California 92008, USA.
Abstract:
Antisense oligonucleotides with 2'-O-(2-[N,N-dimethyl)aminooxy]ethyl) or (2'-O-DMAOE) modification were synthesized and evaluated for nuclease resistance and pharmacology both in vitro and in vivo. This modification exhibits very high nuclease resistance and efficacy in various biological (ICAM-1, C-raf and PKC-alpha) targets.
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