Related Experiment Videos
Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides
V Tomasi1, P P Laktionov, A V Bryksin
1Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemistry, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
Nuclear accumulation of ODNs has been associated with their binding to a series of nuclear proteins. These interactions could be responsible for the sequence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interaction of ODNs with these proteins may shed light on the mechanisms of cellular uptake and nuclear accumulation of oligonucleotides.