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Direct MALDI-TOF MS analysis of oligonucleotides on solid support through a photolabile linker
A Meyer1, N Spinelli, J C Brés
1Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM2, Université Montpellier II, Place E. Bataillon, 34095, Montpellier, France.
Nucleosides, Nucleotides & Nucleic Acids
|September 21, 2001
Abstract:
MALDI-TOF mass spectrometry was used to analyze oligonucleotides still anchored to long-chain alkylamine controlled-pore glass (LCAA-CPG) through a photolabile linker. This technique is useful to follow supported chemical reactions in real time and monitor by-products formation.