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Bacterial meningitis in children: critical care needs
S Singhi1, P Singhi, A K Baranwal
1Pediatric Intensive Care Unit, Department of Pediatrics, Advance Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. drsinghi@glide.net.in
Insights
Critical care for acute bacterial meningitis (ABM) in children significantly reduces mortality. Early life support, antibiotics, and management of complications like raised intracranial pressure (ICP) and seizures are vital for survival.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Background:
- Acute bacterial meningitis (ABM) in children leads to severe complications and high mortality, especially in developing nations.
- Most deaths occur within 48 hours of hospitalization, with coma, raised intracranial pressure (ICP), seizures, and shock as key predictors.
- Effective critical care management is crucial for improving outcomes in pediatric ABM.
Purpose of the Study:
- To review critical care issues in managing pediatric patients with ABM.
- To highlight the importance of prompt life support and management of complications.
- To share experiences from managing 88 children with ABM in a Pediatric Intensive Care Unit (PICU).
Main Methods:
- Focus on basic life support (ABCs), including intubation and oxygen for low Glasgow Coma Scale (GCS) scores.
- Initiation of antibiotics, even without lumbar puncture if contraindicated.
- Management of raised ICP with mannitol and short-term hyperventilation, and treatment of shock with fluids and inotropes.
- Control of seizures with intravenous benzodiazepines and ventilatory support when indicated.
Main Results:
- Prompt attention to ABCs, early antibiotics, and ICP management are essential.
- Aggressive treatment of shock and seizures improves patient stability.
- Ventilatory support is often necessary for respiratory compromise or coma.
- The study highlights the potential for critical care to significantly reduce ABM mortality.
Conclusions:
- Critical care interventions are vital for reducing mortality in pediatric ABM.
- Management should prioritize airway, breathing, circulation, early antibiotics, and ICP control.
- Individualized treatment based on patient presentation and complications is key to successful outcomes.
Abstract:
Acute bacterial meningitis (ABM) in children is associated with a high rate of acute complications and mortality, particularly in the developing countries. Most of the deaths occur during first 48 hours of hospitalization. Coma, raised intracranial pressure (ICP), seizures, shock have been identified as significant predictors of death and morbidity. This article reviews issues in critical care with reference to our experience of managing 88 children with ABM in PICU. Attention should first be directed toward basic ABCs of life-support. Children with Glasgow Coma Scale (GSC) score < 8 need intubation and supplemental oxygen. Antibiotics should be started, even without LP (contraindicated if focal neuro-deficit, papilledema, or signs of raised ICP). Raised ICP is present in most of patients; GCS < 8 and high blood pressure are good guides. Mannitol (0.25 gm/Kg) should be used in such patients. If there are signs of (impending) herniation short-term hyperventilation is recommended; prolonged hyperventilation (> 1 hour) must be avoided. Any evidence of poor perfusion, hypovolemia and/or hypotension needs aggressive treatment with normal saline boluses and inotropes, if necessary, to maintain normal blood pressure. Empiric fluid restriction is not justified. Seizures may be controlled with intravenous diazepam or lorazepam. Refractory status epilepticus may be treated with continuous diazepam (0.01-0.06) mg/kg/min) or midazolam infusion. Ventilatory support may be needed early for associated pneumonia, poor respiratory effort and/or coma, and occasionally to reduce work of breathing in shock. Provision of critical care to children with ABM may reduce the mortality significantly as experienced by us.
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