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Modelling a binuclear metal binding site in the photosynthetic reaction centre II
1Post Graduate Department of Chemistry, Rajendra College, Bolangir 767 002, Orissa, India.
Indian Journal of Biochemistry & Biophysics
|September 21, 2001
Abstract:
Based on the experimental data and homologous sites in Protein Data Bank (PDB) a model for metal binding sites in D1/D2 heterodimer has been proposed. On searching for tetranuclear and binuclear Mn binding sites in the PDB, a suitable sequence homology in thermolysin and D1 could be observed. From the homology and site-directed mutagenesis data, a model for binuclear Mn-Ca or Mn-Mn has been built and it is extended to a tetranuclear Mn centre.