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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

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Related Experiment Video

Updated: Jul 25, 2026

Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

Fetal death. A 10-year retrospective study.

M A Sims1, K A Collins

  • 1Medical University of South Carolina, Charleston, USA.

The American Journal of Forensic Medicine and Pathology
|September 21, 2001
PubMed
Summary

Fetal death, or stillbirth, remains a concern despite declines in some causes. This study analyzed 42 forensic cases from 1990-1999, identifying risk factors and causes of fetal demise.

Area of Science:

  • Forensic Pathology
  • Perinatal Medicine
  • Public Health

Background:

  • Fetal death, defined by WHO, has seen reduced incidence for causes like syphilis and diabetes.
  • However, intrauterine infections, malformations, growth retardation, and abruptio placentae persist as significant causes.
  • Unexplained fetal death and contributing maternal/sociodemographic factors remain critical considerations.

Purpose of the Study:

  • To analyze factors contributing to fetal demise in forensic autopsy cases.
  • To identify specific causes and risk factors associated with fetal death.
  • To improve data collection and classification for better understanding of fetal loss.

Main Methods:

  • Retrospective review of 42 forensic autopsy cases of fetal death/stillbirth (1990-1999).

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  • Analysis included gestational age, sex, race, weight, prenatal care, maternal drug use, autopsy findings, and cause/manner of death.
  • Toxicologic analysis was performed on relevant cases.
  • Main Results:

    • The study population had a black:white ratio of approximately 2:1 and a male:female ratio of 1:1.
    • Most fetuses were >20 weeks gestational age; 7.5% had congenital anomalies.
    • Toxicologic analysis revealed drug use in 21% of cases, including cocaine/benzoylecgonine in 17%.

    Conclusions:

    • Fetal death remains a complex issue with multifactorial causes, including maternal drug use.
    • Lack of uniform data collection hinders comparisons and understanding of fetal death causes.
    • This retrospective study aims to assist death investigators in determining factors leading to fetal demise.