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Human umbilical cord blood cells ameliorate Huntington's disease in transgenic mice

N Ende1, R Chen

  • 1Department of Pathology and Laboratory Medicine, New Jersey Medical School, University of Medicine & Dentistry, Newark 07103, USA.

Journal of Medicine
|September 21, 2001
PubMed

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...