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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
05:37

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Published on: December 22, 2017

Inferior vena cava malformation as a risk factor for deep venous thrombosis in the young

Y L Chee1, D J Culligan, H G Watson

  • 1Department of Haematology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK.

British Journal of Haematology
|September 21, 2001
PubMed

Insights

Inferior vena cava (IVC) anomaly is a rare cause of spontaneous deep vein thrombosis (DVT) in young patients. This congenital condition, potentially leading to venous stasis, was observed at a higher rate than expected in patients with unprovoked DVT.

Area of Science:

  • Vascular Medicine
  • Thrombosis Research
  • Congenital Abnormalities

Background:

  • Hypercoagulable states and venous stasis are known risk factors for deep vein thrombosis (DVT).
  • Recent research highlights acquired risk factors contributing to hypercoagulability.
  • Congenital anomalies of the venous system are less commonly recognized as DVT precursors.

Purpose of the Study:

  • To investigate the potential association between inferior vena cava (IVC) anomalies and spontaneous, unprovoked deep vein thrombosis (DVT) in young patients.
  • To determine if IVC anomalies occur at a higher frequency than expected in this patient demographic.
  • To highlight the diagnostic consideration of IVC anomalies in specific DVT cases.

Main Methods:

  • Retrospective case series analysis over a 3-year period.
  • Identification of patients presenting with spontaneous, unprovoked deep vein thrombosis (DVT).
  • Evaluation for congenital anomalies of the inferior vena cava (IVC).

Main Results:

  • Four young patients with spontaneous, unprovoked DVT were found to have an inferior vena cava (IVC) anomaly.
  • This represents an observed rate of 5%, significantly higher than the expected 0.5%.
  • Three of the four patients with IVC anomaly presented with bilateral deep vein thrombosis (DVT).

Conclusions:

  • Inferior vena cava (IVC) anomaly is a rare but potentially significant congenital condition predisposing to deep vein thrombosis (DVT).
  • The findings suggest IVC anomalies may contribute to DVT development through mechanisms favoring venous stasis.
  • Consideration of IVC anomaly is warranted in young patients presenting with spontaneous and bilateral DVT.

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