Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac basal metabolism.

C L Gibbs1, D S Loiselle

  • 1Department of Physiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, PO Box 13F, Monash University, Victoria 3800, Australia. colin.gibbs@med.monash.edu.au

The Japanese Journal of Physiology
|September 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Historical Perspective: Heat production and chemical change in muscle. Roger C. Woledge.

Progress in biophysics and molecular biology·2021
Same author

Deleterious effects of soluble beta amyloid on cognition, antagonism by saline and noradrenaline, a role for microglia.

Neuroscience·2012
Same author

Comparison of the Gibbs and Suga formulations of cardiac energetics: the demise of "isoefficiency".

Journal of applied physiology (Bethesda, Md. : 1985)·2012
Same author

Relating components of pressure-volume area in Suga's formulation of cardiac energetics to components of the stress-time integral.

Journal of applied physiology (Bethesda, Md. : 1985)·2012
Same author

Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: experiments and modelling.

The Journal of physiology·2012
Same author

A possible mechanism of toxicity by the antidepressant amoxapine based on its effects in three in vitro models.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same journal

Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?

The Japanese journal of physiology·2006
Same journal

Single-channel properties of volume-sensitive Cl- channel in ClC-3-deficient cardiomyocytes.

The Japanese journal of physiology·2006
Same journal

Synthetic peptides of actin-tropomyosin binding region of troponin I and heat shock protein 20 modulate the relaxation process of skinned preparations of taenia caeci from guinea pig.

The Japanese journal of physiology·2006
Same journal

Establishment of a mouse macula densa cell line with an nNOS promoter driving EGFP expression.

The Japanese journal of physiology·2006
Same journal

The medial amygdala controls the coital access of female rats: a possible involvement of emotional responsiveness.

The Japanese journal of physiology·2006
Same journal

Comparison of biomechanical and histological properties in dog carotid arteries injured by neointima or intimal thickening.

The Japanese journal of physiology·2005
See all related articles

The nonbeating heart

Area of Science:

  • Cardiology
  • Biochemistry
  • Physiology

Background:

  • The basal metabolism of the nonbeating heart is not well understood.
  • Cardiac bypass surgery often involves a nonbeating heart, making its metabolic state critical.
  • Existing literature may overestimate the protective effects of hypothermia.

Purpose of the Study:

  • To investigate the range of metabolic rates in the nonbeating heart.
  • To identify factors influencing nonbeating heart metabolism.
  • To explore the role of hypoxia and ischemia in cardiac metabolism and hibernation.

Main Methods:

  • Discussion of technical challenges in measuring in vivo basal metabolism.
  • Analysis of physiological and biochemical factors affecting metabolic rate.

Related Experiment Videos

  • Literature review on hypothermia, hypoxia, ischemia, and cardiac bypass.

    • Main Results:

    • Nonbeating heart metabolism can vary significantly, from near-beating heart levels to a small fraction of normal.
    • Substrate supply is a key physiological factor influencing metabolic rate.
    • The precise biochemical reasons for a significant portion of basal adenosine triphosphate (ATP) usage remain unclear.
    • Hypoxia and ischemia may regulate basal metabolic rate, contributing to cardiac hibernation.

    Conclusions:

    • The metabolic flexibility of the nonbeating heart is substantial.
    • Further research is needed to elucidate the biochemical underpinnings of cardiac ATP usage.
    • Hypoxia and ischemia are potential regulators of cardiac metabolism, relevant to cardiac hibernation and interventions like bypass surgery.