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Self major histocompatibility complex class-II-specific regulatory CD4 T cells prevent both Th1- and Th2-mediated
L Pelletier1, M Savignac, E Xystrakis
1Inserm U28, Hôpital Purpan, place du D Baylac, 31059, Toulouse, France. Lucette.Pelletier@purpan.inserm.fr
Microbes and Infection
|September 21, 2001
Abstract:
It is clear that functional heterogeneity of T cells may be explained by differential cytokine production. The aim of this paper was to review evidence for regulatory cells, generated after HgCl(2)-exposure. They differ from classical Th1 and Th2 cells, produce transforming growth factor-beta and interleukin-10 and exert their regulatory functions in a Th1/Th2-unrestricted fashion.