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Quantifying electrostatic interactions in pharmaceutical solid systems.

¹Institute of Pharmacy, School of Sciences, Pasteur Building, Institute of Pharmacy, University of Sunderland, Sunderland SR23SD, UK. growley@btinternet.com

International Journal of Pharmaceutics

|September 21, 2001

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Triboelectrification of pharmaceutical powders depends on particle size and surface interactions. Powder adhesion and composition changes during charging are influenced by particle size, surface type, and contamination.

Area of Science:

Pharmaceutical Science
Materials Science
Electrostatics

Background:

Triboelectrification is crucial in pharmaceutical powder handling, affecting processing and device performance.
Understanding electrostatic interactions is key for controlling powder flow and preventing issues like adhesion and segregation.

Purpose of the Study:

To investigate triboelectrification of alpha-Lactose monohydrate with stainless steel and polymer surfaces.
To analyze the impact of particle size, mixtures, and surface contamination on electrostatic charging.
To understand composition changes in binary powder mixtures during triboelectrification.

Main Methods:

Utilized a cyclone charger with interchangeable stainless steel and polymer contact surfaces.
Tested various particle size fractions of alpha-Lactose monohydrate, including binary mixtures with fine lactose or micronized salbutamol.

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Analyzed adhered and non-adhered powder compositions using particle size and chemical analyses.

Main Results:

Charge acquisition was inversely related to particle size for single component powders with negligible adhesion.
Triboelectrification became more complex with particulate contamination due to particle-surface and particle-particle interactions.
Compositional changes in binary mixtures were observed, linked to powder-surface affinity and interparticulate forces.

Conclusions:

Particle size significantly influences electrostatic charging of pharmaceutical powders.
Surface contamination and particle interactions complicate triboelectrification, impacting powder mixture homogeneity.
Affinity and interparticulate forces play a role in the separation of components within cohesive powder mixtures during charging.