Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Terbinafine-induced hepatic dysfunction.

W M Chambers1, A Millar, S Jain

  • 1Liver Transplantation and Hepato-biliary Medicine Unit, Royal Free Hospital, Pond St., Hampstead, London UK.

European Journal of Gastroenterology & Hepatology
|September 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in farm management factors on New Zealand dairy farms with divergent bulk milk urea concentration.

Journal of dairy science·2026
Same author

Use of antimicrobials for food animals in New Zealand: updated estimates to identify a baseline to measure targeted reductions.

New Zealand veterinary journal·2021
Same author

Assessing the acceptability of a novel dry powder inhaler A multicentre study in adult asthmatic patients using routine bronchodilator therapy.

Primary care respiratory journal : journal of the General Practice Airways Group·2019
Same author

Assessing the impact of a nurse-delivered home dried blood spot service on uptake of testing for household contacts of hepatitis B-infected pregnant women across two London trusts.

Epidemiology and infection·2016
Same author

Early invasive fungal infections and colonization in patients with cirrhosis admitted to the intensive care unit.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2015
Same author

Cost-effectiveness of noninvasive liver fibrosis tests for treatment decisions in patients with chronic hepatitis B in the UK: systematic review and economic evaluation.

Journal of viral hepatitis·2015

Terbinafine, an antifungal medication, can cause severe liver injury. This case highlights a severe cholestatic reaction, emphasizing the need for monitoring patients on this drug.

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Toxicology

Background:

  • Terbinafine is a widely used antifungal agent.
  • Drug-induced liver injury (DILI) is a significant clinical concern.
  • Cholestatic liver injury can result from various medications.

Observation:

  • A 41-year-old male presented with severe hepatic dysfunction after a 3.5-week course of terbinafine.
  • Symptoms included jaundice, pruritus, malaise, anorexia, and loin pain.
  • Laboratory tests revealed markedly elevated bilirubin and alkaline phosphatase, with a prolonged prothrombin time.

Findings:

  • Transjugular liver biopsy confirmed canalicular cholestasis, indicative of a drug reaction.
  • The patient's condition represents the most severe cholestatic reaction reported to date associated with terbinafine.

Related Experiment Videos

  • Liver function normalized 15 months after discontinuing the medication.

    • Implications:

    • This case underscores the potential for severe hepatotoxicity from terbinafine.
    • Close monitoring of liver function is crucial in patients receiving terbinafine.
    • Recovery is possible even in severe cases without the need for liver transplantation.