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[Epstein-Barr virus-associated pericarditis].

S Lentini1, K Klingel, D Skowasch

  • 1Medizinische Universitätsklinik und Poliklinik II (Direktor: Prof. Dr. B. Lüderitz), Herzzentrum des Universitätsklinikums Bonn, und.

Deutsche Medizinische Wochenschrift (1946)
|September 21, 2001
PubMed
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A woman with pericardial effusion tested positive for Epstein-Barr virus (EBV) via PCR, indicating localized cardiac EBV reactivation. This rare cause of cardiac tamponade resolved without specific treatment.

Area of Science:

  • Cardiology
  • Virology
  • Molecular Diagnostics

Background:

  • Pericardial effusion can lead to cardiac tamponade.
  • Epstein-Barr virus (EBV) is a common virus, but cardiac involvement in adults is rare.

Observation:

  • A 73-year-old woman presented with dyspnea due to a large pericardial effusion.
  • Extensive investigations for malignancy and infection were negative.
  • Nested PCR detected Epstein-Barr virus (EBV) in pericardial fluid and blood leukocytes.

Findings:

  • The findings suggest localized pericardial EBV persistence or reactivation as the cause of the effusion.
  • Molecular tests, like PCR, were crucial for diagnosing this rare condition.
  • The patient's condition resolved spontaneously without further intervention.

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Implications:

  • This case highlights EBV as a potential, albeit uncommon, cause of pericardial effusion and tamponade in adults.
  • It underscores the importance of molecular diagnostic methods in identifying unusual pathogens.
  • Early diagnosis and understanding of EBV's role in cardiac conditions can guide management.