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Related Experiment Videos

Torsade de pointes induced by ajmaline.

W Haverkamp1, G Mönnig, P Kirchhof

  • 1Medizinische Klinik und Poliklinik, Innere Medizin C (Kardiologie, Angiologie) Westfälische Wilhelms-Universität Münster 48129 Münster, Germany. haverkw@uni-muenster.de

Zeitschrift Fur Kardiologie
|September 22, 2001
PubMed
Summary

Ajmaline, an antiarrhythmic drug, can cause dangerous heart rhythm abnormalities like QT prolongation and Torsade de Pointes. This highlights the need for caution when using ajmaline, especially in patients with heart rhythm issues.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Ajmaline is a Class I antiarrhythmic agent.
  • It is derived from reserpine.
  • Ajmaline is used for treating ventricular tachyarrhythmias and as a diagnostic tool.

Observation:

  • Two cases of ajmaline-induced abnormal QT prolongation were observed.
  • These cases were accompanied by polymorphic ventricular tachycardia of the Torsade de Pointes type.

Findings:

  • Ajmaline administration led to significant QT interval prolongation.
  • The drug induced Torsade de Pointes, a life-threatening arrhythmia.

Implications:

  • Caution is advised when prescribing ajmaline due to its proarrhythmic potential.
  • Monitoring the QT interval is crucial in patients receiving ajmaline.

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  • The risk of Torsade de Pointes should be considered in patients with underlying cardiac conditions.