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Related Experiment Videos

Electrical potential difference between basal cell carcinoma, benign inflammatory lesions and normal tissue.

R E Woodrough, G Canti, B W Watson

    The British Journal of Dermatology
    |January 1, 1975
    PubMed
    Summary

    Measuring skin electrical potential difference shows basal cell carcinoma differs significantly from normal skin. However, overlapping results make this method currently unsuitable for diagnosis.

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    Area of Science:

    • Dermatology
    • Medical Diagnostics
    • Biophysics

    Background:

    • Basal cell carcinoma (BCC) is a common skin cancer.
    • Accurate and non-invasive diagnostic methods for BCC are needed.
    • Electrical potential differences on the skin surface may offer diagnostic insights.

    Purpose of the Study:

    • To investigate the potential of measuring resting electrical potential difference (EPD) on the skin surface as a diagnostic tool for basal cell carcinoma.
    • To compare EPD measurements between BCC lesions, benign inflammatory lesions, and normal skin.

    Main Methods:

    • Resting electrical potential difference was measured on the skin surface of patients with suspected BCC.
    • Measurements were taken on BCC lesions, benign inflammatory lesions, and contralateral normal skin.

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  • A reference electrode was placed under the tongue for all measurements.

    • Main Results:

    • Mean EPD for basal cell carcinomas was +11 mV.
    • Mean EPD for benign inflammatory lesions was +2 mV.
    • Mean EPD for normal skin was -3 mV.
    • EPD differences between BCC and normal skin were highly significant (P < 0.1%).
    • Differences between inflammatory lesions and normal skin were statistically insignificant.

    Conclusions:

    • While basal cell carcinoma exhibits a significantly different mean electrical potential difference compared to normal skin, the considerable overlap in measurements limits its current utility.
    • The resting electrical potential difference measurement, in its present form, is not a reliable diagnostic technique for basal cell carcinoma due to population overlap.