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Related Experiment Videos

Nestin expression in cortical dysplasia.

N Duggal1, S Iskander, R R Hammond

  • 1Department of Clinical Neurological Sciences, London Health Sciences Centre and The University of Western Ontario, Canada.

Journal of Neurosurgery
|September 22, 2001
PubMed
Summary

Cortical dysplasia (CD) may harbor immature cells expressing nestin, a precursor marker. These dysmature cells, potentially neurons or astrocytes, may contribute to glioneuronal neoplasms and seizures associated with CD.

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Area of Science:

  • Neuroscience
  • Pathology
  • Developmental Biology

Background:

  • Cortical dysplasia (CD) is linked to a higher risk of glioneuronal neoplasms.
  • Immature cells within CD might be precursors to these tumors.
  • Nestin, a marker for neuroepithelial precursor/stem cells, was investigated in CD.

Purpose of the Study:

  • To characterize nestin expression in cortical dysplasia (CD).
  • To correlate nestin expression with pathological and clinical features of CD.
  • To investigate the nature of nestin-positive cells in CD.

Main Methods:

  • Review of clinical and surgical features in 10 CD cases.
  • Immunohistochemical analysis of nestin, MAP2, neurofilament, and GFAP.
  • Confocal scanning laser microscopy to assess antigen expression.

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Main Results:

  • Nestin, glial, and neuronal antigens were found in specific cells within CD regions.
  • Nestin-positive cells comprised a mixed population.
  • Some cells were identified as dysmature neurons (nestin+, MAP2+), others as astrocytes (nestin+, GFAP+).

Conclusions:

  • Nestin-positive cells in CD represent a mixed population of immature neurons and astrocytes.
  • Understanding these cells may illuminate the pathogenesis of glioneuronal tumors and seizures in CD.