Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Omental transplantation for epilepsy.

H Rafael, R Mego

    Journal of Neurosurgery
    |September 22, 2001
    PubMed
    Summary
    This summary is machine-generated.

    Residual seizures after hemispherectomy can stem from residual frontal basal tissue, even after extensive disconnection. Complete resection of this dysplastic tissue is crucial for seizure freedom in some epilepsy cases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vascular anomalies of the medulla oblongata.

    Acta neurochirurgica·2007
    Same author

    Mesencephalic ischemia and Parkinson's disease.

    Journal of neurology, neurosurgery, and psychiatry·2004
    Same author

    Omental transplantation for temporal lobe epilepsy: report of two cases.

    Neurology India·2002
    Same author

    Cerebrovascular surgery: past, present, and future.

    Neurosurgery·2001
    Same author

    Modern neurosurgery for psychiatric disorders.

    Neurosurgery·2001
    Same author

    Omental transplantation for Alzheimer's disease.

    Neurology India·2001

    Area of Science:

    • Neurology
    • Neurosurgery
    • Epileptology

    Background:

    • Functional hemispherectomy is a treatment for catastrophic epilepsy, but residual seizures occur in about 20% of patients.
    • These seizures are often attributed to incomplete disconnection or persistent epileptogenic foci.

    Observation:

    • A case study of an 8-year-old boy with intractable seizures due to extensive left hemispheric cortical dysplasia is presented.
    • Initial surgery involved removing dysplastic tissue and transecting the motor strip, followed by hemispherectomy for persistent seizures.
    • After a seizure-free period, new seizures emerged, localized to deep ipsilateral structures, specifically residual frontobasal tissue.

    Findings:

    • Despite standard hemispherectomy, residual frontal basal cortex can harbor epileptogenic foci, particularly if dysplastic.

    Related Experiment Videos

  • Complete resection of this residual frontobasal tissue led to sustained seizure freedom in the reported case.
  • Advanced imaging techniques like electroencephalography and SPECT were vital in localizing residual epileptic discharges.

    • Implications:

    • This case highlights the importance of considering residual, dysplastic frontobasal tissue as a source of refractory seizures post-hemispherectomy.
    • Thorough assessment of residual tissue is critical before deeming epilepsy refractory to surgical treatment.
    • Findings suggest a potential refinement in surgical techniques for catastrophic epilepsy to ensure complete resection of all epileptogenic zones.