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Application of PNA and LNA oligomers to chemotherapy
1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75390-9041, USA.
Current Opinion in Investigational Drugs (London, England : 2000)
|September 22, 2001
Abstract:
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.