Commercial fibrin sealants in surgical care

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The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
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The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Published on: November 4, 2010

W D Spotnitz1

  • 1Department of Surgery, University of Florida School of Medicine, Box 100286, Gainesville, Florida 32610-0286, USA. spotnitz@surgery.ufl.edu

American Journal of Surgery
|September 22, 2001
PubMed

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.