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Tissue sealing.

T Morikawa1

  • 1Division of Cancer Medicine, Hokkaido University Graduate School of Medicine and Second Department of Surgery, Hokkaido University Hospital, North 15, West 7, Kita-ku, 060-8638, Sapporo, Japan. t-morika@med.hokudai.ac.jp

American Journal of Surgery
|September 22, 2001
PubMed
Summary
This summary is machine-generated.

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Fibrin sealants, derived from fibrinogen, are widely used in surgery for effective tissue sealing. These sealants reduce bleeding and complications, improving surgical outcomes across various procedures.

Area of Science:

  • Biomedical Engineering
  • Surgical Innovation
  • Wound Healing

Background:

  • Fibrinogen's adhesive properties were noted 60 years ago, but widespread surgical use of fibrin sealants began with concentrated plasma fibrinogen and bovine thrombin.
  • Fibrin sealants are now integral to numerous surgical fields, including cardiothoracic, gastrointestinal, neurosurgery, and vascular surgery.

Purpose of the Study:

  • To review current applications of fibrin sealants in surgical tissue sealing.
  • To highlight the improved surgical outcomes associated with fibrin sealant use.

Main Methods:

  • Review of existing literature and clinical practices regarding fibrin sealant application.
  • Analysis of surgical outcomes data, focusing on blood loss, operative time, and complications.

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Main Results:

  • Fibrin sealants effectively control hemorrhage and blood loss from difficult-to-suture tissues.
  • Use of fibrin sealants reduces perioperative and postoperative complications such as fluid/air leakage and fistula formation.
  • The fibrin clot is biocompatible and naturally degraded during wound healing.

Conclusions:

  • The application of fibrin sealants in surgery is expanding to new procedures and patient populations.
  • Increased availability of commercial fibrin sealants is leading to broader adoption and improved patient outcomes.
  • Fibrin sealants offer significant benefits in reducing blood loss, operative time, and postoperative complications.