Fibroblast growth factor signalling in mouse mammary gland development
B Spencer-Dene1, C Dillon, V Fantl
1Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Endocrine-Related Cancer
|September 22, 2001
Summary
Fibroblast growth factors (Fgfs) are crucial for mammary gland development from embryogenesis through pregnancy. This study highlights Fgf signalling
Area of Science:
- Developmental biology
- Cell signaling
- Cancer research
Background:
- Fibroblast growth factors (Fgfs) and their receptors are key intercellular signaling molecules.
- Aberrant Fgf expression or receptor activation is linked to tumorigenesis.
- Fgfs play roles in various aspects of animal development.
Purpose of the Study:
- To investigate the role of Fgf signaling in mammary gland development.
- To examine Fgf's function during embryogenesis and pregnancy.
Main Methods:
- The study focused on mouse mammary gland development.
- Evidence was gathered on Fgf signaling's role.
Main Results:
- Fgf signaling is critical for mammary primordia formation during embryogenesis.
- Fgf signaling is necessary for optimal lobuloalveolar development during pregnancy.
Conclusions:
- Fgf signaling is essential for mammary gland development at multiple stages.
- Understanding Fgf's role can inform cancer research.
