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Left ventricular systolic dysfunction in a biracial sample of hypertensive adults: The Hypertension Genetic

R B Devereux1, J N Bella, V Palmieri

  • 1Weill Medical College of Cornell University, New York, NY, USA. rbdevere@med.cornell.edu

Hypertension (Dallas, Tex. : 1979)
|September 22, 2001
PubMed

Insights

Left ventricular systolic dysfunction is common in hypertensive patients, particularly in men and those with diabetes. Key factors include male gender, black race, elevated uric acid, and specific echocardiographic findings.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Left ventricular systolic dysfunction (LVSD) is a significant complication of hypertension.
  • Understanding the prevalence and correlates of LVSD is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence of left ventricular systolic dysfunction in a biracial population with hypertension.
  • To identify clinical and echocardiographic correlates of LVSD in this population.

Main Methods:

  • A population-based sample of 2086 hypertensive participants from the Hypertension Genetic Epidemiology Network (HyperGEN) study.
  • Clinical evaluation and echocardiography were performed to assess left ventricular function and structure.
  • Statistical analyses, including regression, were used to identify correlates of LVSD.

Main Results:

  • 86% had normal ejection fraction, 10% mild dysfunction, and 4% severe dysfunction.
  • LVSD was more prevalent in men than women and weakly associated with diabetes.
  • Independent correlates of lower ejection fraction included male gender, black race, prior myocardial infarction, higher ventricular mass, and lower relative wall thickness.

Conclusions:

  • Left ventricular systolic dysfunction is prevalent in hypertensive patients.
  • Male gender, black race, diabetes, and elevated uric acid levels are associated with LVSD.
  • Echocardiographic parameters like ventricular mass and relative wall thickness are important indicators of LVSD.

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