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Patterson correlation methods: a review of molecular replacement with CNS
R W Grosse-Kunstleve1, P D Adams
1Lawrence Berkeley National Laboratory, One Cyclotron Road, Mail Stop 4-230, Berkeley, CA 94720, USA. rwgrosse-kunstleve@lbl.gov
Acta Crystallographica. Section D, Biological Crystallography
|September 22, 2001
Summary
This review covers molecular replacement principles and their implementation in the Crystallography and NMR System (CNS). It details key methods like the direct rotation function for structural biology research.
Area of Science:
- Structural biology
- Crystallography
Background:
- Molecular replacement is a key technique in solving crystal structures.
- Understanding its principles is crucial for researchers.
Purpose of the Study:
- To review the fundamental principles of molecular replacement.
- To discuss the implementation of molecular replacement within the Crystallography and NMR System (CNS).
Main Methods:
- Detailed discussion of the direct rotation function.
- Explanation of Patterson correlation refinement.
- Overview of the fast translation function.
Main Results:
- The paper provides a comprehensive overview of molecular replacement methods.
- It highlights the specific implementation within the CNS software package.
Conclusions:
- The Crystallography and NMR System (CNS) offers a robust implementation of molecular replacement.
- CNS is freely available to academic users, facilitating structural biology research.