Related Experiment Videos
Isolated paraaortic lymph node recurrence after definitive irradiation for cervical carcinoma
1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. ma2012@adm.cgmh.org.tw
International Journal of Radiation Oncology, Biology, Physics
|September 25, 2001
Summary
Isolated paraaortic lymph node recurrence after cervical cancer radiotherapy is treatable with salvage concurrent chemoradiation (CCRT). Early detection through tumor marker surveillance and asymptomatic presentation are key prognostic factors for improved survival.
Area of Science:
- Gynecologic Oncology
- Radiation Oncology
- Medical Oncology
Background:
- Cervical cancer recurrence after radiotherapy can involve isolated paraaortic lymph nodes (PALN).
- Understanding prognostic factors and salvage treatment efficacy is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate clinical features of isolated PALN recurrence post-radiotherapy.
- To identify prognostic factors for isolated PALN recurrence.
- To assess the effectiveness of salvage treatment for isolated PALN recurrence.
Main Methods:
- Retrospective analysis of 876 patients treated with pelvic radiotherapy for cervical carcinoma.
- Inclusion criteria: isolated PALN recurrence as the first recurrence site, controlled primary tumor, no distant metastases.
- Salvage treatments included concurrent chemoradiation (CCRT), radiation alone, or chemotherapy alone.
Main Results:
- Seven of 26 patients with isolated PALN recurrence survived disease-free.
- All survivors received salvage CCRT (radiation to PALN + cisplatin-based chemotherapy).
- A 5-year survival rate of 51.2% was observed for patients receiving salvage CCRT. Asymptomatic presentation and SCC levels < or = 4 ng/ml were associated with better survival.
Conclusions:
- Asymptomatic presentation and low SCC levels (< or = 4 ng/ml) are favorable prognostic factors for isolated PALN recurrence.
- Salvage CCRT offers a significant survival benefit.
- Periodical surveillance with tumor markers and imaging aids early detection and salvage treatment.