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Is activated factor VII associated with retinal vein occlusion?
S Kadayifçilar1, D Ozatli, O Ozcebe
1Department of Ophthalmology, Hacettepe University School of Medicine, Turkey. sibelkd@mailcity.com
The British Journal of Ophthalmology
|September 25, 2001
Summary
Elevated levels of activated factor VII (FVIIa) are associated with retinal vein occlusion (RVO). This thrombophilia factor may contribute to the development of both central and branch RVO.
Area of Science:
- Ophthalmology
- Hematology
- Vascular Medicine
Background:
- Retinal vein occlusion (RVO) is a significant cause of vision loss.
- The role of thrombophilia in RVO pathophysiology is an area of ongoing research.
- Activated factor VII (FVIIa), a newly identified thrombophilia factor, warrants investigation for its potential association with RVO.
Purpose of the Study:
- To investigate the association between activated factor VII (FVIIa) and retinal vein occlusion (RVO).
- To compare FVIIa levels in RVO patients with those in a control group.
Main Methods:
- A case-control study included 54 RVO patients (22 CRVO, 32 BRVO) and 19 controls.
- Ophthalmoscopic examination, medical history, and blood analyses were performed.
- Coagulation factors, including FVIIa, were measured and compared between groups.
Main Results:
- FVIIa levels were significantly higher in the RVO group compared to the control group (p=0.0004).
- No significant difference in FVIIa levels was observed between central RVO (CRVO) and branch RVO (BRVO) groups.
- Hypertension was prevalent in BRVO cases; other hematological parameters were largely within normal limits.
Conclusions:
- Elevated activated factor VII (FVIIa) levels are significantly associated with retinal vein occlusion (RVO).
- FVIIa may play a role in the pathophysiology of both central and branch retinal vein occlusion.
- No other tested hematological parameters showed significant differences from the control group.