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Coats disease: smaller volume of the affected globe
P Galluzzi1, C Venturi, A Cerase
1Unit of Diagnostic and Therapeutic Neuroradiology, Azienda Ospedaliera Senese, Siena, Italy. neurorad@ao-siena.tocscana.it
Insights
Children with Coats disease often have a smaller affected ocular globe volume compared to their healthy eye. This finding helps differentiate Coats disease from other conditions like retinoblastoma.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Medical Imaging
Background:
- Coats disease is a rare condition causing abnormal blood vessel development in the retina.
- Distinguishing Coats disease from other pediatric eye conditions, such as retinoblastoma, is crucial for appropriate management.
Purpose of the Study:
- To investigate whether a smaller volume of the affected ocular globe is a characteristic feature of Coats disease.
Main Methods:
- Ocular globe volume was measured using computed tomography (CT) and magnetic resonance imaging (MRI) scans in children diagnosed with Coats disease and unilateral retinoblastoma.
- Anteroposterior and equatorial diameters were used for volume estimation.
- Statistical analyses, including univariate and multivariate methods, were employed.
Main Results:
- Children with Coats disease exhibited a significantly smaller mean volume in the affected globe compared to the normal globe (P = .002).
- In contrast, children with retinoblastoma did not show a statistically significant trend towards a larger affected globe volume (P = .088).
- The difference in globe volume was the only significant independent variable in children with Coats disease.
Conclusions:
- A significantly reduced volume of the affected ocular globe is identified as an additional diagnostic feature of Coats disease.
- This finding may aid in the differential diagnosis of pediatric retinal disorders.
Purpose:
To determine whether a significant smaller volume of the affected globe, compared with that of the normal globe, is an additional feature of Coats disease.
Materials And Methods:
Ocular globe volume was assessed in 13 children (11 boys, two girls; age range, 0.6-14 years; mean age, 4.1 years) with Coats disease and in 18 (eight boys, 10 girls; age range, 0.5-12 years; mean age, 3.6 years) with unilateral retinoblastoma. Orbital computed tomographic scans were available for all children; magnetic resonance images were available for 11 children-seven with Coats disease and four with retinoblastoma. For volume estimation, anteroposterior and equatorial diameters of ocular globes were measured. Statistical analysis was conducted with univariate and multivariate methods.
Results:
In children with Coats disease, the mean volume of the affected globe was 4,877.03 mm(3) (range, 2,951.47-6,284.70 mm(3)) and that of the normal globe, 6,018.00 mm(3) (range, 4,062.32-7,509.26 mm(3)). In children with retinoblastoma, the mean volume of the affected globe was 4,557.06 mm(3) (range, 1,612.01-7,463.00 mm(3)) and that of the normal globe, 4,402.11 mm(3) (range, 1,360.46- 7,463.00 mm(3)). The Coats disease population had a significantly smaller volume of the affected globe (z = -3.1009; P =.002); the retinoblastoma population did not have a statistically significant trend toward a bigger affected globe volume (z = -1.7064; P =.088). The difference between the affected globe volume and the normal globe volume in children with Coats disease was the only significant independent variable (P =.005).
Conclusion:
A significantly smaller volume of the affected globe is an additional feature of Coats disease.