Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recovery from vestibular ototoxicity.

F O Black1, C Gianna-Poulin, S C Pesznecker

  • 1Neurotology Research, Legacy Clinical Research and Technology Center, Portland, Oregon 97208-3950, USA.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|September 25, 2001
PubMed
Summary

Vestibular ototoxicity can impair vestibular function, with gain constant recovery more common than time constant recovery. Discontinue ototoxic medications promptly upon detecting vestibulo-ocular reflex changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of eccentric rotation on the human pitch vestibulo-ocular reflex.

Acta oto-laryngologica·2008
Same author

Influence of imaginary target on "dumping" of vestibulo-ocular reflexes and postural control.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2004
Same author

Vestibular prostheses: the engineering and biomedical issues.

Journal of vestibular research : equilibrium & orientation·2003
Same author

What can posturography tell us about vestibular function?

Annals of the New York Academy of Sciences·2001
Same author

Medical investigations and resulting countermeasures in support of 16-day Space Shuttle missions.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2001
Same author

Can imaginary head tilt shorten postrotatory nystagmus?

Experimental brain research·2001

Area of Science:

  • Otolaryngology
  • Neuroscience
  • Pharmacology

Background:

  • Vestibular ototoxicity, often caused by medications, can lead to significant functional deficits.
  • Understanding the recovery dynamics of vestibular function after ototoxicity is crucial for patient management.

Purpose of the Study:

  • To determine if subjects with documented vestibular ototoxicity recover vestibular function.
  • To investigate the recovery patterns and dynamics of vestibular function following ototoxic drug exposure.

Main Methods:

  • Prospective and retrospective review of 28 subjects treated with vestibulotoxic medications.
  • Repeated measures of horizontal canal vestibulo-ocular function, with comparison to a normal database.
  • Recording of auditory and vestibular symptoms.
Keywords:
NASA Discipline NeuroscienceNon-NASA Center

Related Experiment Videos

Main Results:

  • 39% of subjects showed vestibular ototoxicity affecting gain constant (GC) and/or time constant (TC).
  • Eight of nine subjects recovered GC to normal limits within one year; only one of eight recovered TC.
  • Ototoxicity onset and recovery were independent of baseline function and cumulative drug dose; no correlation with symptoms.

Conclusions:

  • Recovery of GC is more frequent than TC recovery following vestibular ototoxicity.
  • Ototoxic effects manifest unpredictably; early discontinuation of ototoxic medication is recommended upon detecting vestibulo-ocular reflex changes.