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A multicapillary inlet jet disruption electrodynamic ion funnel interface for improved sensitivity using atmospheric
1Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
Analytical Chemistry
|September 25, 2001
Summary
A novel multicapillary inlet and ion funnel for electrospray ionization-mass spectrometry boosts ion transmission efficiency. A jet disrupter further improves performance and reduces pumping requirements, enhancing sensitivity for trace analysis.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
Background:
- Conventional electrospray ionization-mass spectrometry (ESI-MS) interfaces face limitations in ion transmission efficiency.
- Longer distances between the ESI capillary and ion funnel can increase gas load, impacting performance.
Purpose of the Study:
- To develop and evaluate a new multicapillary inlet and ion funnel interface for ESI-MS.
- To improve ion transmission efficiency and reduce gas load compared to standard interfaces.
Main Methods:
- Development of a multicapillary inlet and ion funnel interface for ESI-MS.
- Incorporation of a jet disrupter within the ion funnel to manage gas flow.
- Comparison of ion transmission efficiency and sensitivity with and without the jet disrupter against a standard interface.
Main Results:
- The multicapillary interface achieved higher ion transmission efficiency.
- The jet disrupter improved ion transmission by 15% and reduced pumping speed requirements by 2-3 fold.
- Signal enhancement of 5.3-14.1 fold was observed in MS/MS operation for trace samples.
Conclusions:
- The developed multicapillary inlet and ion funnel with a jet disrupter significantly enhances ESI-MS sensitivity.
- This interface design is effective for analyzing samples at low concentrations, overcoming limitations of conventional systems.
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