Chemotherapy of sarcomas

The development of intensive treatment techniques with combination chemotherapy, radiation, and selected surgery has produced dramatic improvements in the treatment of soft tissue sarcomas. This has been best demonstrated in the long-term disease-free survival of a majority of children with inoperable or metastatic embryonal rhabdomyosarcoma treated with VAC chemotherapy (vincristine, actinomycin D, and cyclophosphamide). The addition of adriamycin and imidazole carboxamide to the combination therapy program for adults with soft tissue sarcomas has resulted in significant improvements in their response rates as well.