Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioinformatics: use in bacterial vaccine discovery.

R J Zagursky1, D Russell

  • 1Wyeth Lederle Vaccines, West Henrietta, NY 14586, USA. zagursrj@war.wyeth.com

Biotechniques
|September 26, 2001
PubMed
Summary

Bioinformatics accelerates bacterial vaccine discovery by enabling rapid genomic sequence analysis. Computational tools identify and characterize potential surface targets, streamlining the process before laboratory work begins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Early Trial-Based Cost-Effectiveness Analysis of Extracorporeal Shockwave Therapy for Diabetes Related Foot Ulcer Healing.

International wound journal·2026
Same author

Extracorporeal Shockwave Therapy for Diabetes Related Foot Ulcers: A Pilot Three-Arm Double-Blinded Randomised Controlled Trial.

International wound journal·2025
Same author

Renal impairment risk in Indigenous and non-Indigenous people who take HIV pre-exposure prophylaxis (PrEP): a retrospective cohort study.

Sexual health·2025
Same author

A Pilot Three Arm Randomised Controlled Trial and Qualitative Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcer Healing (SOLEFUL): A Study Protocol.

International wound journal·2025
Same author

The development of an EU-wide nutrition and physical activity expert knowledge base to support a personalised mobile application across various EU population groups.

Nutrition bulletin·2024
Same author

USA Department of Defense audit of surgical antibiotic prophylaxis prescribing patterns in inguinal hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2020

Area of Science:

  • Bioinformatics and Genomics
  • Computational Biology
  • Vaccine Development

Background:

  • Bioinformatics integrates genomics, proteomics, and transcriptional profiling.
  • Complete genomic sequences, particularly from prokaryotes, facilitate rapid gene identification and analysis.
  • Wet laboratory research can be preceded by in silico analysis for gene target selection.

Purpose of the Study:

  • To review genomic mining tools and algorithms for bacterial vaccine discovery.
  • To focus on predicting open reading frames, annotation, characterization, and localization.
  • To provide examples of bioinformatics applications in identifying bacterial vaccine candidates.

Main Methods:

  • Genomic sequence analysis using various algorithms.
  • Prediction of open reading frames (ORFs).
  • Functional and cellular localization characterization of gene targets.

Main Results:

  • Bioinformatics enables rapid identification of potential surface targets in bacterial genomes.
  • Computational tools facilitate the characterization of these gene targets.
  • Primers for cloning can be produced based on in silico analysis.

Conclusions:

  • Genomic mining accelerates the identification of potential bacterial vaccine candidates.
  • Bioinformatics significantly streamlines the early stages of vaccine discovery.
  • In silico methods reduce the time and resources required before experimental validation.

Related Experiment Videos