Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factors modulating benzidine carcinogenicity bioassay.

S D Vesselinovitch, K V Rao, N Mihailovich

    Cancer Research
    |October 1, 1975
    PubMed
    Summary

    Benzidine dihydrochloride exposure causes various tumors in mice, with liver tumors being most prevalent. Female mice showed higher susceptibility to benzidine-induced liver cancer than males.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Understanding the magnetic interaction between intrinsic defects and impurity ions in room-temperature ferromagnetic Mg1-xFexO thin films.

    Journal of physics. Condensed matter : an Institute of Physics journal·2016
    Same author

    Spatial and temporal estimation of soil loss for the sustainable management of a wet semi-arid watershed cluster.

    Environmental monitoring and assessment·2016
    Same author

    Brassica RNA binding protein ERD4 is involved in conferring salt, drought tolerance and enhancing plant growth in Arabidopsis.

    Plant molecular biology·2015
    Same author

    Spatial and temporal estimation of runoff in a semi-arid microwatershed of Southern India.

    Environmental monitoring and assessment·2015
    Same author

    Model and scenario variations in predicted number of generations of Spodoptera litura Fab. on peanut during future climate change scenario.

    PloS one·2015
    Same author

    Disorder-induced room temperature ferromagnetism in glassy chromites.

    Scientific reports·2014

    Area of Science:

    • Toxicology
    • Carcinogenesis
    • Animal Models

    Background:

    • Benzidine dihydrochloride is a known carcinogen.
    • Understanding factors influencing its carcinogenicity is crucial for risk assessment.

    Purpose of the Study:

    • To assess factors influencing benzidine dihydrochloride carcinogenicity in mice.
    • To evaluate dose, duration, and age at exposure on tumor development.

    Main Methods:

    • C57BL/6J X C3HeB/FeJ F1 mice (male and female) were used.
    • Exposure routes included oral administration in food and stomach intubation.
    • Dose levels ranged from 30 µg/mouse to 150 ppm, with durations from 3 to 84 weeks.
    • Tumor incidence was evaluated at 90 weeks of age.

    Main Results:

    • Benzidine treatment induced liver tumors, lung adenomas, Harderian gland cystadenomas, and lymphoreticular neoplasms.
    • Continuous feeding for 84 weeks showed a dose-response relationship for liver tumors, with higher incidence in females.
    • Infant exposure (3-week intubation) significantly increased liver tumors in males.

    Conclusions:

    • Factors like dose, duration, and age at exposure significantly modulate benzidine carcinogenicity.
    • Females exhibit greater susceptibility to benzidine-induced hepatocarcinogenesis.
    • Early-life exposure, particularly in males, is a critical factor for liver tumor development.

    Related Experiment Videos