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Extent of coronary atherosclerosis and homocysteine affect endothelial markers

A Yildirir1, S L Tokgozoglu, I Haznedaroglu

  • 1Hacettepe University, Department of Cardiology, Ankara, Turkey. ayliny@ato.org.tr

Angiology
|September 26, 2001
PubMed

Insights

Vascular cell adhesion molecule-1 and sE-selectin indicate coronary artery disease presence. C-reactive protein, troponin I, and leukocyte counts predict clinical stability in patients with coronary artery disease.

Area of Science:

  • Cardiology
  • Biochemistry
  • Immunology

Background:

  • Coronary artery disease (CAD) involves atherosclerosis, impacting endothelial function.
  • Biomarkers like C-reactive protein (CRP) and homocysteine are implicated in CAD pathogenesis.
  • Adhesion molecules play a role in the inflammatory processes of atherosclerosis.

Purpose of the Study:

  • To assess how CAD presence, extent, and stability affect endothelial function, CRP, and homocysteine.
  • To identify specific biomarkers associated with CAD presence and clinical status.

Main Methods:

  • Evaluated 58 CAD patients and 25 controls for risk factors, plasma homocysteine, CRP, and soluble adhesion molecules.
  • Measured vascular cell adhesion molecule-1 (VCAM-1) and sE-selectin levels.
  • Analyzed correlations between biomarkers, CAD extent, and clinical stability (stable vs. unstable angina).

Main Results:

  • VCAM-1 and sE-selectin were significantly higher in CAD patients versus controls.
  • Unstable angina patients showed elevated CRP, troponin I, and leukocyte counts compared to stable angina patients.
  • sE-selectin correlated with CAD extent; VCAM-1 correlated with homocysteine in unstable cases.

Conclusions:

  • VCAM-1 and sE-selectin are valuable markers for detecting coronary atherosclerosis.
  • CRP, troponin I, and leukocyte count serve as predictors of clinical instability in CAD.
  • Biomarker profiles can help differentiate CAD presence and assess disease severity and stability.

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