Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of substance P in the parabrachial nucleus of multiple system atrophy.

H Nomura1, H Konno, S Takase

  • 1Department of Neurology, Kohnan Hospital, Sendai, Japan.

Autonomic Neuroscience : Basic & Clinical
|September 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of combined GABA and L-theanine supplementation on sleep quality: an exploratory study.

European review for medical and pharmacological sciences·2026
Same author

Impact of hospital volume on risk-adjusted mortality following oesophagectomy in Japan.

The British journal of surgery·2016
Same author

Synthesis of Squamostanal-A.

Bioscience, biotechnology, and biochemistry·2016
Same author

Diverse roles of STING-dependent signaling on the development of cancer.

Oncogene·2015
Same author

Hemodynamic assessment of celiaco-mesenteric anastomosis in patients with pancreaticoduodenal artery aneurysm concomitant with celiac artery occlusion using flow-sensitive four-dimensional magnetic resonance imaging.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2013
Same author

Influence of age and gender on human lymphatic pumping pressure in the leg.

Lymphology·2011

Multiple system atrophy (MSA) patients with autonomic failure show a significant reduction in substance P (SP) nerve fibers within the parabrachial nucleus (PBN). This suggests SP pathways to the PBN are involved in MSA

Area of Science:

  • Neuroscience
  • Autonomic Nervous System Research
  • Neurodegenerative Diseases

Background:

  • The parabrachial nucleus (PBN) regulates autonomic functions.
  • Substance P (SP) containing nerve fibers modulate PBN transmission.
  • The nucleus of the solitary tract (NTS) projects SP fibers to the PBN.

Purpose of the Study:

  • To investigate the role of substance P (SP) pathways in the autonomic failure of multiple system atrophy (MSA).
  • To compare SP-like immunoreactive (SPLI) nerve fiber terminals in the PBN of MSA patients and controls.

Main Methods:

  • Postmortem brain tissue from four MSA patients with autonomic failure and four healthy controls were analyzed.
  • Immunohistochemical staining for SP was performed on pons sections containing the PBN.

Related Experiment Videos

  • Histopathological evaluation included assessment of astrocytosis for neuron preservation.

    • Main Results:

    • A marked decrease in SP-like immunoreactive (SPLI) nerve fiber terminals was observed in the PBN of all MSA patients compared to controls.
    • Obvious astrocytosis was present in the PBN of MSA patients, indicating neuronal damage.

    Conclusions:

    • The projecting SP pathway to the PBN is significantly diminished in MSA patients with autonomic failure.
    • These findings suggest that the SP pathway to the PBN plays a crucial role in the pathophysiology of autonomic dysfunction in MSA.