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Recurrent pneumococcal bacteremia: risk factors and outcomes.
G S Turett1, S Blum, E E Telzak
1Section of Infectious Diseases, Department of Medicine, Saint Vincents Hospital and Medical Center, Cronin Bldg, Room 1003, 153 W 11th St, New York, NY 10011, USA. gsturett@onebox.com
Archives of Internal Medicine
|September 26, 2001
Summary
Recurrent pneumococcal bacteremia occurs more often than previously thought, particularly in immunocompromised individuals. Investigating underlying immunodeficiencies is crucial for managing these recurrent infections.
Area of Science:
- Infectious Diseases
- Bacteriology
- Epidemiology
Background:
- Recurrent pneumococcal bacteremia is infrequently documented.
- Often associated with immunocompromised patient populations.
Purpose of the Study:
- To determine risk factors for recurrent pneumococcal bacteremia.
- To assess outcomes, including mortality and antimicrobial resistance, of recurrent cases.
Main Methods:
- Retrospective review of pneumococcal bacteremia cases (1992-1996).
- Abstraction of demographic, clinical, and laboratory data.
- Analysis of recurrence rates, risk factors, and outcomes.
Main Results:
- A 5.3% recurrence rate was observed, higher than previously reported.
- Human immunodeficiency virus (HIV) infection, cancer, and female sex predicted recurrence.
- Recurrent isolates showed increased penicillin resistance; mortality was higher in recurrent cases.
Conclusions:
- The incidence of recurrent pneumococcal bacteremia may be underestimated.
- Investigating underlying immunodeficiency is recommended for patients with recurrent pneumococcal bacteremia.
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