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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Effect of mobile phase amine additives on enantioselectivity for phenylalanine analogs

Y K Ye1, R Stringham

  • 1Dupont Pharmaceutical Company, Chemical Process Research and Development, Deepwater, NJ 08023, USA. yun.k.ye@dupontpharma.com

Journal of Chromatography. A
|September 27, 2001
PubMed

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Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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