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Unlocking mysteries of gut sensory transmission: is adenosine the key?
1Department of Anesthesiology, Physiology, and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA.
Abstract:
Endogenous adenosine acts at pre- or postsynaptic A1, A2, or A3 receptors to inhibit synaptic transmission in intrinsic primary afferent/AH neurons, S neurons, and mucosal and motility reflexes. Adenosine provides dual modulation of adenylyl cyclases. Its modulation of sensory transmission may be of therapeutic potential in gut inflammation, ischemia, and constipation.