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Oxatomide in the treatment of atopic dermatitis in breast-fed and very young infants

A Boccazzi1, L Pugni, R Cesuti

  • 1Istituto di Clinica Pediatrica, Università degli Studi, Milan, Italy.

Minerva Pediatrica
|September 27, 2001
PubMed

Insights

Oxatomide oral suspension effectively treated atopic dermatitis in infants and young children. This study found significant improvements in itching and skin symptoms, demonstrating the treatment

Area of Science:

  • Pediatric Dermatology
  • Clinical Pharmacology

Background:

  • Atopic dermatitis (AD) is a common inflammatory skin condition in infants and young children.
  • Management of AD in this age group presents unique challenges due to safety and administration considerations.

Purpose of the Study:

  • To evaluate the efficacy and safety of oxatomide oral suspension for treating atopic dermatitis in breast-fed and young babies.
  • To assess the usability of oxatomide oral suspension in pediatric patients.

Main Methods:

  • A 30-day treatment study involving 31 children (4-35 months old) with atopic dermatitis.
  • Oxatomide (2.5 mg/mL) was administered at 1 mg/kg/day, divided into two doses every 12 hours.
  • Efficacy was measured by changes in itching, erythema, blisters, papules, scratching lesions, and dry skin.

Main Results:

  • Significant improvements were observed in skin signs of atopic dermatitis.
  • Itching reduced by 58.2% and erythema by 57.6% (p<0.001).
  • Other symptoms including vesicles, papules, scratching lesions, and dry skin also showed significant improvement. Only one child discontinued treatment due to worsening dermatitis.

Conclusions:

  • Oxatomide oral suspension is effective and safe for treating atopic dermatitis in infants and young children.
  • The simple dosage schedule makes the oral suspension particularly convenient for children under two years old.
Abstract

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