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[Human herpes virus and malignancies].

S Mori1

  • 1Division of Pathology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|September 28, 2001
PubMed
Summary

Epstein Barr virus (EBV) and human herpesvirus 8 (HHV8) are human oncoviruses linked to various cancers. Histopathology aids in diagnosing these herpesvirus-associated tumors.

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Area of Science:

  • Oncology
  • Virology
  • Pathology

Context:

  • Human herpesviruses, specifically Epstein Barr virus (EBV) and human herpesvirus 8 (HHV8), are recognized as significant contributors to human malignancies.
  • EBV is a prevalent human oncovirus implicated in diverse lymphomas, including Burkitt's lymphoma, Hodgkin's disease, and diffuse large B-cell lymphoma.
  • HHV8 is associated with primary effusion lymphoma, certain solid lymphomas, and Castleman's disease.

Purpose:

  • To review the oncogenic roles of EBV and HHV8 in human cancers.
  • To highlight the spectrum of malignancies associated with these two herpesviruses.
  • To emphasize the diagnostic utility of histopathology in identifying herpesvirus-associated tumors.

Summary:

  • Epstein Barr virus (EBV) and human herpesvirus 8 (HHV8) are human oncoviruses that can lead to various cancers.
  • EBV is linked to numerous lymphoma subtypes, while HHV8 is associated with primary effusion lymphoma, solid lymphomas, and Castleman's tumor.
  • Advancements in histopathologic techniques facilitate the routine and accurate diagnosis of these virus-associated malignancies.

Impact:

  • Improved understanding of viral oncogenesis.
  • Enhanced diagnostic capabilities for herpesvirus-related cancers.
  • Potential for targeted therapeutic strategies against oncovirus-driven malignancies.

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