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Review of management of purpura fulminans and two case reports

J Nolan1, R Sinclair

  • 1Department of Anaesthesia, Treliske Hospital, Truro, Cornwall, UK.

British Journal of Anaesthesia
|September 28, 2001
PubMed

Insights

Purpura fulminans (PF) is a rare, severe hemorrhagic condition often linked to infection. While treatments have improved, it remains disabling, frequently leading to amputations.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Dermatology

Background:

  • Purpura fulminans (PF) is a critical hemorrhagic condition.
  • It is frequently associated with sepsis or preceding infections.
  • Key features include disseminated intravascular coagulation, small vessel thrombosis, and tissue necrosis.

Observation:

  • The acute infectious form, often caused by Gram-negative organisms, can lead to multi-organ failure.
  • An idiopathic variant typically manifests with skin-limited manifestations.
  • Two cases of Purpura fulminans are presented.

Findings:

  • Mortality rates for PF have declined due to advancements in treating secondary infections and supportive care.
  • Despite improved outcomes, PF continues to be a disabling condition.
  • Major amputations are often necessitated by the severity of the condition.

Implications:

  • This review highlights the importance of timely and comprehensive management of Purpura fulminans.
  • Understanding the diverse presentations and treatment options is crucial for improving patient outcomes.
  • Further research into novel therapeutic strategies may reduce long-term disability associated with PF.

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