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Prophylaxis for paclitaxel hypersensitivity reactions
1Department of Pharmacy, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA. kintzelpe@aol.com
Objective:
To evaluate clinical literature supporting the prophylactic use of single-dose intravenous dexamethasone to prevent hypersensitivity reactions (HSRs) to paclitaxel infusion.
Data Sources:
Clinical literature accessed through MEDLINE (from 1986 to 2000).
Data Synthesis:
Prophylaxis for paclitaxel-related HSRs generally includes repeated dexamethasone doses beginning 12 hours before paclitaxel, and administration of diphenhydramine plus a histamine2-receptor antagonist 30 minutes before infusion of paclitaxel. Singe-dose intravenous dexamethasone administered with ancillary medications 30 minutes before infusion of paclitaxel has been used to prevent regimen-related HSRs.
Conclusions:
Single-dose intravenous dexamethasone can be used in combination with appropriate ancillary medications to prevent paclitaxel-related HSRs.