Prophylaxis for paclitaxel hypersensitivity reactions

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¹Department of Pharmacy, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA. kintzelpe@aol.com

The Annals of Pharmacotherapy

|September 28, 2001

Abstract

Objective:

To evaluate clinical literature supporting the prophylactic use of single-dose intravenous dexamethasone to prevent hypersensitivity reactions (HSRs) to paclitaxel infusion.

Data Sources:

Clinical literature accessed through MEDLINE (from 1986 to 2000).

Data Synthesis:

Prophylaxis for paclitaxel-related HSRs generally includes repeated dexamethasone doses beginning 12 hours before paclitaxel, and administration of diphenhydramine plus a histamine2-receptor antagonist 30 minutes before infusion of paclitaxel. Singe-dose intravenous dexamethasone administered with ancillary medications 30 minutes before infusion of paclitaxel has been used to prevent regimen-related HSRs.

Conclusions:

Single-dose intravenous dexamethasone can be used in combination with appropriate ancillary medications to prevent paclitaxel-related HSRs.

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