"Fleximers". Design and synthesis of two novel split nucleosides
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Updated: Aug 15, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA. katherine.seley@chemistry.gatech.edu
Abstract:
[structure: see text] A new class of shape-modified nucleosides is introduced. The purine heterobases of adenosine and guanosine have been split into their imidazole and pyrimidine components, thereby introducing flexibility while retaining the elements necessary for recognition. As a consequence, these novel "fleximers" should find use as bioprobes for investigating enzyme-coenzyme binding sites as well as nucleic acid and protein interactions. Their design and synthesis is described.
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