Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macrolides: structures and microbial targets.

J Retsema1, W Fu

  • 1Pfizer Global Research and Development, Pfizer Central Research, Groton, CT 06340, USA. retsema@99main.com

International Journal of Antimicrobial Agents
|September 28, 2001
PubMed
Summary

Macrolide antibiotics effectively treat respiratory infections by inhibiting bacterial protein synthesis. Newer macrolides like azithromycin offer broad-spectrum activity, expanding treatment options despite emerging resistance mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association between childhood trauma and the number of disorders of gut-brain interaction diagnosed in adults, as well as the mediating role of personality disorder traits and anxiety].

Zhonghua yi xue za zhi·2026
Same author

Novel magnetic resonance imaging (MRI)-based radiomics for predicting perineural invasion in rectal cancer: a two-centre study.

Clinical radiology·2025
Same author

Clinicopathological features and prognosis of patients with colorectal Mucinous adenocarcinoma mixed with other pathological components: a nationwide retrospective study in China.

Techniques in coloproctology·2025
Same author

[Myocardial scar area predicts major adverse cardiovascular events after coronary artery bypass grafting in patients with ischemic cardiomyopathy].

Zhonghua xin xue guan bing za zhi·2024
Same author

[Progress of circulating tumor DNA in the clinical management of colorectal cancer].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2024
Same author

[Impact of different diagnostic criteria for assessing mild micro-hepatic encephalopathy in liver cirrhosis: an analysis based on a prospective, multicenter, real-world study].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2023

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Macrolide antibiotics are a cornerstone in treating community-acquired respiratory tract infections.
  • Chemical modifications of the macrolide structure have yielded agents with diverse antimicrobial activities.
  • Macrolides function by inhibiting bacterial protein synthesis via binding to the 50S ribosomal subunit.

Purpose of the Study:

  • To review the established role and evolving applications of macrolide antibiotics.
  • To highlight the mechanisms of action and resistance associated with macrolides.
  • To emphasize the significance of newer macrolides, such as azithromycin, in clinical practice.

Main Methods:

  • Literature review of macrolide antibiotic research and clinical applications.

Related Experiment Videos

  • Analysis of macrolide structure-activity relationships.
  • Examination of bacterial resistance mechanisms to macrolides.

    • Main Results:

    • Macrolides are crucial for treating respiratory infections, acting on the 50S ribosome to inhibit bacterial growth.
    • Clinical resistance arises from 50S subunit modification or efflux pumps.
    • Newer macrolides, exemplified by azithromycin, possess broad-spectrum activity, enhancing their therapeutic utility.

    Conclusions:

    • Macrolide antibiotics remain essential in managing respiratory infections.
    • Understanding resistance mechanisms is key to optimizing macrolide therapy.
    • Azithromycin and similar agents have broadened the clinical utility of macrolides.