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Published on: November 16, 2016
Non-antimicrobial activities of macrolides
1University of London, 31 St. Olav's Court, 25 Lower Road, London SE16 2XB, UK. jdw@ischemo.demon.co.uk
International Journal of Antimicrobial Agents
|September 28, 2001
Summary
Macrolides, commonly used for infections, offer non-antimicrobial benefits like improved gut motility and immune modulation. Future research may yield new macrolide-based drugs targeting these unique pharmacological properties.
Area of Science:
- Pharmacology
- Microbiology
- Gastroenterology
Background:
- Macrolides are primarily known for their antimicrobial properties.
- Non-microbiological effects of macrolides have been observed during infectious disease treatment.
Purpose of the Study:
- To explore the non-antimicrobial effects of macrolides.
- To investigate the potential therapeutic applications of these properties.
Main Methods:
- Literature review of observed macrolide side-effects and potential benefits.
- Analysis of preliminary evidence for immunomodulatory and antitumour activities.
Main Results:
- Macrolides can stimulate gastrointestinal motility, aiding patients with motility disorders.
- Macrolides exhibit immunomodulatory effects, potentially beneficial for chronic inflammatory conditions.
- Preliminary data suggest macrolides possess antitumour activity.
Conclusions:
- Macrolides have diverse pharmacological properties beyond antimicrobial action.
- These properties, including prokinetic, immunomodulatory, and antitumour effects, warrant further investigation.
- Future macrolide drug development may focus on these non-antimicrobial applications.
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