Screening standards in assisted reproduction technologies: the screening of semen donors--where do we draw the line?

The most recent British Andrology Society guidelines have certainly stirred up much debate about the exclusion of donors that are seropositive for cytomegalovirus (CMV). Arguments will inevitably go back and forth regarding the statistical risk of donors passing on infection and the point at which that risk becomes unacceptable. As with many of these debates, a number of different opinions will be offered but a consensus will be almost impossible. However, the case of CMV highlights difficulties common to the screening of donors for many infectious and genetic disorders.